Stabilization of Pharmaceuticals to oxidative degradation

February 6, 2017

A guide for stabilization of pharmaceuticals to oxidation is presented as a guide for formulators. Click here to access the document.

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Hydrolysis in Pharmaceutical formulations

February 6, 2017

A literature review of hydrolysis in active pharmaceutical ingredients and the effects on dosage form stability due to hydrolysis of excipients. Click here to access the document.

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Use of Oxygen Scavengers to Stabilize Solid Pharmaceutical Dosage Forms: A Case Study

February 6, 2017

A case study is described where degradation of solid pharmaceutical dosage form susceptible to oxidation is minimized by incorporation of oxygen scavenger as part of packaging. Click here to gain access to document.

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Impurities in Drug Products: Handbook of Isolation and Characterization of Impurities in Pharmaceuticals, Volume 5

February 6, 2017

  An overview focused on those impurities brought into drug product system by excipients or dosage form processing likely to cause stability or performance issues in the dosage form. Click here to access document.

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Accelerated aging: Prediction of chemical stability of pharmaceuticals

February 6, 2017

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Relative Humidity Hysteresis in Solid-State Chemical Reactivity: A Pharmaceutical Case Study

February 6, 2017

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Highlights of the ASAPdesign Tool

January 30, 2017

FreeThink’s new video highlighting ASAPdesign TM.  

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ASAPprime® Excursions Video

January 30, 2017

A new video describing how ASAPprime®  includes excursions in its calculations.

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ASAPprime® Report Generation Video

January 30, 2017

Watch our new video that highlights the Reports feature in ASAPprime®.

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Predictive Dissolution/Disintegration Stability Modeling: Case Studies

November 28, 2016

For two immediate release tabletted products, short-term accelerated stability studies were used to determine dissolution and disintegration failure times at a range of stress conditions, which then was propagated back to ambient storage conditions based on the moisture-modified Arrhenius equation.  The onset of dissolution failures appears to be sudden and directly correlated to changes in […]

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