ASAPprime in July 2017 Issue of AAPS Newsmagazine

July 12, 2017

AAPS.org and the July 2017 issue of AAPS Newsmagazine recently published an article on FreeThink’s ASAPprime® accelerated stability software titled, “Predicting Drug Dissolution with ASAPprime®” AAPS Open editor-in-chief, Christopher M. Riley, Ph.D., coauthored and presented research on using ASAPprime® software to predict changes in drug dissolution from an immediate-release tablet containing two active pharmaceutical ingredients using […]

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Pfizer: Lean Stability: Global Regulatory Reception—Successes and Challenges of Recent Case Studies

December 8, 2016

Presentation by Dr. Freed, AAPS Stability Workshop 2016 (Washington)    

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Bayer Health Care: Application of the Accelerated Stability Assessment Program (ASAP) to a Liquid Dosage Form Containing Multiple Active Ingredients: A Case Study

November 28, 2016

Poster by Dr. Foyeke Badejo, AAPS 2016 (Denver) ASAP study conducted in three weeks was used successfully to predict liquid drug product shelf-lives (25oC/60%RH). Moreover, the mechanistic insight gained helped to rationalize the impact of flavor components on the product. Click here to view poster description.                   […]

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GSK Consumer: Accelerated Stability Modeling for Nicotine Patch

November 28, 2016

Poster by Dr. Chen, AAPS 2016 (Denver) The study result indicated that it was possible to conduct accelerated stability study in just two weeks and use various stability modeling software and methods to project the shelf life of nicotine patch packed in a foil pouch under ICH conditions. To conduct ASAP studies and perform stability […]

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Eli Lilly: Implementing an Accelerated Stability Assessment Program: Case Study

November 28, 2016

Presentation by Dr. Hyzer at IVT’s Third Annual Forum on Stability Programs, 2012 (San Diego) Click here to view presentation.

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Vertex: Prediction of the Changes in Drug Dissolution from an Immediate-Release Tablet Containing Two Active Pharmaceutical Ingredients Using an Accelerated Stability Assessment Program (ASAPprime®)

November 28, 2016

The computer program ASAPprime® has been used successfully for some time to predict the stability of active pharmaceutical ingredients (APIs) in solid-dosage forms. In this study, we have demonstrated that the ASAPprime® program can also be used to predict the slow-down in dissolution of two APIs in an immediate release tablet. The tablets were pre-equilibrated […]

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Modeling of In-use Stability for Tablets and Powders in Bottles

November 28, 2016

A model is presented for determining the time when an active pharmaceutical ingredient in tablets/powders will remain within its specification limits during an in-use period; that is, when a heat-induction sealed bottle is opened for fixed time periods and where tablets are removed at fixed time points. This model combines the Accelerated Stability Assessment Program […]

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Understanding and Predicting Pharmaceutical Shelf-Life

November 23, 2016

In the Handbook of Stability Testing in Pharmaceutical Development, Dr. Ken Waterman discusses how products are assigned a shelf-life which determines the time when a product is considered safe and effective under a relevant storage condition.  A number of factors are used to assign that shelf-life. Click here to access the document.         […]

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Janssen: ASAP Concept and Case Study

November 21, 2016

Presentation by Dr. Thielges, Informa Life Sciences, 2013 (London) Click here to view presentation.

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GSK Consumer Health: Accelerated Stability Assessment Study for Nicorette® Lozenge

November 21, 2016

Poster by Dr. Chen, AAPS 2013 (San Antonio) Click here for a closer view

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