Problems with Volatiles
Many compounds generate volatile degradation products. These can limit the shelf-life of a product, either because of objectionable odors, or because these materials can themselves cause degradation of the active ingredient. Packaging can play a role in trapping these volatiles or removing them.
Determining Impact on Stability
At FreeThink, we can determine in a short time whether volatile agents influence the shelf-life of a product. Studies in both confined and open environments using our accelerated stability processes (including ASAPprime®) can determine the degree to which these materials impact the stability. Among the more common issues, is the problem of volatile formaldehyde reacting with gelatin capsules, which can be observed by dissolution changes.
Quantitation of Volatiles
Our team at FreeThink can determine the amount of many volatiles using either chemical trapping agents or gas chromatography methods.
Impact of Relative Humidity/Oxygen
In many cases, moisture and oxygen can play significant roles in the formation of volatile agents. We have developed the science and methodology to understand how these factors directly impact the shelf-life, and are expert at combining them with packaging for Moisture Protection or packaging for Oxygen Protection.
Stabilization of actives or reduction of odor can often both be achieved using adsorbants, particularly activated carbon. At FreeThink, we have studied the use of various adsorbants and can quickly select appropriate ones for client needs. While we work with a number of commercial vendors, we partner with Clariant to bring their packaging expertise to our clients.